New Trial Aims to Improve Genetic Risk Communication in Colorectal Cancer

In time for Colorectal Cancer Awareness Month this March, the Alliance for Clinical Trials in Oncology has launched a new clinical study focused on improving how patients with colorectal cancer share genetic risk information with their families. The trial, titled “Family Communications After Genetic Testing,” is supported by grants from the National Cancer Institute and aims to enroll approximately 4,000 colorectal cancer patients and their at-risk relatives across the United States. Alliance for Clinical Trials in Oncology, ScienMag, EurekAlert!

The Importance of Family History

Approximately 30% of colorectal cancer cases are linked to genetic factors and around 15% of newly diagnosed patients have a gene change – known as a pathogenic germline variant – that increases their cancer risk. Alliance for Clinical Trials in Oncology When a family member is found to have an inherited gene change, close relatives, including parents, children, and siblings, may also carry the same gene. Early detection through increased screening and preventative measures can significantly improve treatment outcomes.

Comparing Communication Methods

The clinical trial will compare two different approaches to sharing genetic test results with family members:

• Proband-mediated communication: The patient personally shares the information with their relatives.
• Provider-mediated communication: A healthcare provider directly contacts family members to explain the genetic findings and recommend testing.

Researchers aim to determine which method is more effective in encouraging at-risk family members to undergo genetic testing.

Study Goals

Through this study, researchers hope to understand:

• How many first-degree relatives complete genetic testing using each communication approach.
• Whether relatives who learn they carry a gene change seize steps to protect their health, such as increased screening (colonoscopies or at-home testing kits), within 12 months.
• How communication approaches work for different demographic groups, including varying ages, ethnicities, and geographic locations (rural vs. Urban).

Who Can Participate?

The trial is open to individuals diagnosed with colorectal cancer, stages I to IV, within the previous three months. Alliance for Clinical Trials in Oncology

Addressing Communication Challenges

“Sharing genetic information can be stressful and confusing, especially right after a cancer diagnosis,” said Frank Sinicrope, MD, study co-chair and a gastroenterologist at the Mayo Clinic in Rochester, Minn. “Some patients aren’t sure how to explain test results, while others worry about upsetting loved ones. This study hopes to identify a clear, helpful approach that makes it easier for families to understand their risks and take preventive action.” Alliance for Clinical Trials in Oncology

For more information on the trial, visit ClinicalTrials.gov.