Structural changes in the brain during menopause
White matter hyperintensities and neurological risks
Research has also shown an increase in white matter hyperintensities, especially in women who experience premature menopause or frequent hot flashes. White matter hyperintensities appear as bright areas on MRI scans of the white matter in the brain and usually indicate tissue damage caused by reduced blood supply. These abnormalities are associated with symptoms such as cognitive decline, balance problems and mood swings. They are also associated with an increased risk of stroke and dementia.
Brain recovery, estrogen receptors and neural adaptation
Some studies suggest that gray matter volume may partially recover after menopause, which could indicate the brain’s adaptability through neuroplasticity. Researchers have also observed a higher density of estrogen receptors during menopause. This increase could be a response by the brain to falling hormone levels, although it has also been linked to poorer memory performance. Changes in cerebrovascular reactivity and changes in brain energy metabolism further highlight how menopause can impact neurological health and resilience.
date:2026-02-14 15:12:00
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