FORMS, AND YOU MAY HAVE HEARD OF SOME GENE MUTATIONS LIKE BRCA1 OR BRCA2, BUT THERE’S ANOTHER ONE THAT YOU MAY NOT HAVE HEARD OF, AND IT’S CHEK2. MERCY MEDICAL CENTER DOCTOR NEIL FRIEDMAN JOINS US NOW WITH MORE INFORMATION. GOOD MORNING. NICE TO BE HERE. THANK YOU. YEAH.THANK YOU SO MUCH FOR JOINING US. LOOK, WE WE HEAR ABOUT ALL OF THESE DIFFERENT MUTATIONS. AND HOW DO THEY REALLY IMPACT THE PATIENT.WELL IF YOU HAVE A MUTATION IT’S A HUGE IMPACT. YOU HAVE TO RECOGNIZE THAT ONLY ABOUT 10 TO 15% OF ALL BREAST CANCERS ARE BASED ON THE FAMILY HISTORY AND BASED ON MUTATION. MOST ARE WHAT WE CALL SPORADIC MUTATIONS. BUT IF YOU HAVE ONE OF THOSE MUTATIONS, IT CAN DRAMATICALLY INCREASE YORU RISK FOR DEVELOPING BREAST CANCER. DOES THESE DO THESE MUTATIONS RATHER IMPACT THE SEVERITY OF THE CANCER? NO, NOT NECESSARILY. SOME DO IN THE SENSE THAT BRCA ONE,YOU CAN HAVE A TRIPLE NEGATIVE BREAST CANCER WHICH IS A MORE AGGRESSIVE BREAST CANCER. BUT THEY INCREASE THE INCIDENCE BRCA ONE AND TWO. YOUR LIFETIME RISK CAN BE AS HIGH AS 60 TO 80% FOR GETTING BREAST CANCER. THE CHEK2 GENE MUTATION IS WHAT WE CALL A MODERATE RISK MUTATION. SO THE RISK FOR DEVELOPING BREAST CANCER IS DRAMATICALLY LOWER BUT STILL CAN BE IN THE MID TO HIGH 20S TO MAYBE EVEN HIGHER,DEPENDING ON YOUR FAMILY HISTORY. WHEREAS A NORMAL RISK FOR BREAST CANCER FOR WOMEN IS ABOUT 12%.SO IT’S SEVERAL TIMES HIGHER. WHY IS IT CRUCIAL TO MAKE THESE DISTINCTIONS? BRCA1, BRCA2, CHEK2.SO THE CRITICALLY IMPORTANT THING I
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